Enhanced Vasodilator Activity of Nitrite in Hypertension
نویسندگان
چکیده
منابع مشابه
Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential.
Elevation of circulating nitrite (NO2(-)) levels causes vasodilatation and lowers blood pressure in healthy volunteers. Whether these effects and the underpinning mechanisms persist in hypertension is unknown. Therefore, we investigated the consequences of systemic nitrite elevation in spontaneously hypertensive rats and conducted proof-of-principle studies in patients. Nitrite caused dose-depe...
متن کاملIs circulating nitrite a directly acting vasodilator?
It can, therefore, be assumed that NO− # could act as an indirect vasodilator. In an article recently published in Clinical Science, Demoncheaux et al. [1] have addressed this issue by performing sophisticated experiments in vitro with rings of pulmonary arteries, and reported that the concentration of NO− # derived from dissolved NO (NO solv ) in aqueous solutions of NaNO # at pH 7.4 cannot ac...
متن کاملcomparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولThe potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions.
By acting as a bioreactor, affording chemical and mechanical conditions for the reaction between dietary components, the stomach may be a source of new bioactive molecules. Using gas chromatography-mass spectrometry we here demonstrate that, under acidic gastric conditions, ethyl nitrite is formed in microM concentrations from the reaction of red wine or distilled alcoholic drinks with physiolo...
متن کاملHistory of hypertension and enhanced thrombogenic activity in postinfarction patients.
Hypertension is a risk factor for coronary thrombosis and death in cardiac patients mediated in part by endothelial damage or dysfunction and increased thrombogenicity. However, there are no data regarding the association between hypertension and thrombogenic activity in stable patients after myocardial infarction and limited data about the prognostic significance of thrombogenic factors in hyp...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2013
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.111.00933